Pain is a subjective sensation that can be described in terms of intensity, duration, location and quality. Among these, pain intensity is most important as it best reflects the degree of discomfort. Pain is always a neuropsychological phenomenon that has an unpleasant intrusive nature. At present a number of drugs are being used for induction of anaesthesia. Ever since its introduction in clinical scenario in 1977, propofol has attained unmatched popularity as an agent for intravenous induction. It is also used for short duration of surgery, day care surgery, sedation and ambulatory surgery. But very often it has the disadvantage of causing pain or discomfort on injection specially when given in small veins on the dorsum of hand. Among 33 clinical problems, propofol induced pain ranked seventh when both clinical importance and frequency were considered. Incidence of pain with intravenous propofol is quite high. A number of both pharmacological and non-pharmacological methods are used to decrease pain on propofol injection but none has been proved absolutely perfect for attenuation of pain due to propofol injection. Thus, this prospective randomized double blind study was conducted to attenuate the pain on propofol injection by pre-treatment with palonosetron, magnesium sulfate and nitroglycerine.
Loading....